Lung Cancer Research Foundation Announces Research Collaboration with Israel Cancer Research Fund
Groups partner on research project to test innovative new treatment for KRAS-mutant cancer being developed at Hebrew University
NEW YORK, Feb. 18, 2025 /PRNewswire/ -- The Lung Cancer Research Foundation (LCRF) is pleased to announce its partnership with Israel Cancer Research Fund (ICRF) on a project led by Joel Yisraeli, PhD, and his lab in the Department of Developmental Biology and Cancer Research at the Hebrew University of Jerusalem. The ICRF-LCRF Project Grant is a three-year, $180,000 award.
The project, titled "Treating Lung and Colorectal Carcinomas by Targeting IGFBP1" will study the effects of an IGF2BP1 inhibitor discovered by Professor Yisraeli and his team, building upon previous ICRF-funded research.
IGF2BP1 is a protein that binds to RNA and is usually active before birth, but it becomes active again in many types of cancers. In patients with lung adenocarcinoma, those with high levels of IGF2BP1 and a mutated KRAS gene have a much lower survival rate (15 months) compared to those without high levels of IGF2BP1 (88 months). In mice, when IGF2BP1 is active along with the mutant KRAS gene, it helps tumors grow in the lungs and spread to other parts of the body. However, blocking IGF2BP1 can prevent these tumors from spreading.
Prof. Yisraeli's lab discovered and refined a molecule called "AVJ16," which prevents IGF2BP1 from attaching to KRAS and other cancer-promoting RNAs. In mouse models, this drug stops cancer cells from growing when injected under the skin. This project will allow Prof. Yisraeli and his team to test AVJ16 in a genetic mouse model of lung cancer, explore its potential as an additional therapy, and develop a small molecule that targets and degrades IGF2BP1. Their ultimate goal is to create a set of powerful new therapies that specifically inhibit IGF2BP1 and prevent cancer development. They hope these animal studies will be the first step toward a clinical trial.
KRAS is the most common mutation in non-small cell lung cancer patients, making up about 25% of all lung cancers. The KRAS gene serves as a signaling pathway for cell growth, and when there is a mutation in the KRAS gene, it causes excess signaling, leading to excess cell growth and cancer. Roughly half of patients with KRAS-mutated lung cancer have a KRAS G12C mutation1, for which there are targeted drug therapies following progression after first-line treatment. However, because these agents are not curative nor active in other KRAS mutations, additional research is urgently needed.
Professor Yisraeli has received previous grant funding from ICRF over the years, including when he initially set up his lab at the Faculty of Medicine at Hebrew University after returning from a post-doctoral fellowship in developmental biology at Harvard. This support has enabled new discoveries and paved the way for his current lung cancer research.
"LCRF is delighted to partner with ICRF on this research project," says Antoinette Wozniak, MD, LCRF Chief Scientific Officer. "In a notoriously difficult cancer to treat, this project explores a promising new target for KRAS-mutated lung cancer, which is an exciting development."
"I'm grateful for this powerful partnership between ICRF and LCRF," says Arnold Baskies, MD, FACS, Chair of ICRF's Board of Trustees. "Our collaboration amplifies our shared vision to advance lung cancer treatment while leveraging Israel's innovations in the fight against cancer."
To learn more about LCRF and its grants program, visit LCRF.org. To learn more about ICRF and its research program, visit icrfonline.org.
About the Lung Cancer Research Foundation (LCRF)
The Lung Cancer Research Foundation® (LCRF) is the leading nonprofit organization focused on funding innovative, high-reward research with the potential to extend survival and improve quality of life for people with lung cancer. LCRF's mission is to improve lung cancer outcomes by funding research for the prevention, diagnosis, treatment, and cure of lung cancer. To date, LCRF has funded 428 research grants, totaling nearly $48 million, the highest amount provided by a nonprofit organization dedicated to funding lung cancer research. For more information, visit lcrf.org.
Contact:
Sheila Sullivan
Sr. Director, Marketing & Communications, LCRF
ssullivan@lcrf.org
About Israel Cancer Research Fund (ICRF)
Israel Cancer Research Fund (ICRF) is the largest nongovernmental funder of cancer research in Israel. For 50 years, with nearly 3,000 grants totaling more than $98 million, ICRF has enabled the best and brightest scientists to conduct groundbreaking research for all types of cancer across Israel's leading institutions. Our goal is to end the suffering caused by cancer and ensure that Israel remains a global leader in science and a beacon of hope for the world. The answer to cancer is research! Learn more at icrfonline.org.
Contact:
Gayle Peck
Director of Communications, ICRF
gayle.peck@icrfonline.org
About the Hebrew University of Jerusalem
This year marks 100 years of excellence in research, education, and innovation at the Hebrew University of Jerusalem, Israel's premier institution of higher learning and research. The University is dedicated to advancing knowledge, fostering leadership, and promoting diversity, serving over 23,000 students from over 80 countries. As home to founder Albert Einstein's archives, the University produces nearly 40% of Israel's civilian scientific research and has received over 11,000 patents. Faculty and alumni of the Hebrew University have won eight Nobel Prizes and a Fields Medal, and continue to shape the future. For more information about Hebrew University's academic programs, research, and achievements, please visit http://new.huji.ac.il/en.
Contact:
Danae Marks-Callaf
Director of International Communications
danaemc@savion.huji.ac.il
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SOURCE Lung Cancer Research Foundation