Elysium Health™ Announces the Launch of COFACTOR™: An advanced 4-in-1 Collagen System With NAD+ Boost

The first and only product formulated to increase collagen production by addressing multiple root causes of aging and collagen decline

NEW YORK, March 13, 2025 /PRNewswire/ -- Elysium Health, Inc.™, a leading life sciences company focused on aging research, today announced the launch of COFACTOR™ by Elysium Health, a first-of-its-kind, proven collagen supplement that delivers complete support by providing the building blocks to increase collagen production and by addressing multiple root causes of collagen decline—aged fibroblasts, decline in NAD+, and decline in hyaluronic acid (HA). Developed by the experts in aging, Cofactor targets the most critical cellular components associated with the age-related loss of collagen. Its unique formulation combines grass-fed collagen peptides with the clinically proven NAD+ booster nicotinamide riboside (NR), hyaluronic acid (HA), and the essential collagen cofactor vitamin C, which together make up its 4-in-1 system. Working throughout the body, the ingredients in Cofactor are clinically proven to significantly improve skin texture, wrinkles, dermal density (a reflection of the amount of structural components like collagen and elastin), and moisture for a more youthful appearance, as well as support resilient joints, healthy bones, and hair and nail health.

With age, the number of fibroblasts (cells that produce collagen) goes down. Moreover, the remaining fibroblasts produce less collagen. While supplementing with collagen alone provides some clinical benefit, addressing multiple root causes of aging in the collagen system—fibroblasts, NAD+, and HA—is a far more comprehensive and powerful approach. Research has repeatedly demonstrated the cellular health benefits of restoring NAD+ to youthful levels. Preclinical evidence also shows that aged fibroblasts treated with NAD+ precursors produce more collagen—like more youthful fibroblasts. Cofactor's 4-in-1 system takes a complete cellular approach to supporting collagen, the body's most abundant protein.

"The global collagen market is projected to reach $14.4 billion by 2033, driven by rising health awareness, increasing demand for functional foods and supplements, and interest in skin care and joint health products," said Elysium Health CEO Eric Marcotulli. "Even so, we were unable to identify any available products that address key drivers of collagen decline, including aging. We developed Cofactor to offer a comprehensive solution—addressing several root causes of aging that impact collagen synthesis, loss, and degradation." 

With age, levels of NAD+, collagen, and HA all go down. By age 40, collagen levels have dropped by about 25%, and the decline of NAD+ is a hallmark feature of aging. In skin, NAD+ levels decrease by almost 60% between young adulthood and middle age, impacting the health and function of the cells that produce collagen as well as other components necessary for maintaining skin health and structure. HA is critical to the health of the extracellular matrix, which surrounds and supports cells and tissues in the body. Its decline impacts collagen production and maintenance.

Cofactor is designed to restore all three molecules:

• Grass-fed collagen peptides provide the building blocks and stimulus for collagen production, and vitamin C functions as an essential cofactor for collagen synthesis, providing proven health benefits for skin, hair, nails, bones, and joints
• NR is clinically proven to raise NAD+ to youthful levels, which creates a youthful cellular environment for collagen and ceramide synthesis and helps to combat collagen degradation
• Oral HA increases levels of HA throughout the extracellular matrix of the skin and further supports a youthful cellular environment for collagen production and maintenance, improving skin elasticity, hydration, and barrier function

"The four ingredients in Cofactor's unique formulation are designed to work synergistically," said Elysium Health chief scientist and Novartis Professor of Biology at MIT Leonard Guarente, Ph.D. "NAD+ to combat aging and promote cellular health, collagen peptides for collagen support, HA for moisture, and vitamin C to aid collagen synthesis."

About Elysium Health™
Elysium Health's™ mission is to solve the biggest challenges in health with science, to help people lead healthier lives. Working directly with the world's leading scientists and clinicians, Elysium Health™ is committed to translating critical advancements in aging research into health solutions people can access today. Learn more at www.elysiumhealth.com.

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SOURCE Elysium Health